Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7

Molecules

Yu Wang³  Da-Hong Li¹  Zhan-Lin Li¹  Yan-Jun Sun²  Hui-Ming Hua¹  Tao Liu³  Jiao Bai¹ 

[1] Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China;Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang 110122, China;

关键词: marine-derived fungus;    Aspergillus fumigatus;    terpenoid;    cell growth inhibition;   

DOI  :  10.3390/molecules21010031

来源: mdpi

【 摘 要 】

Two new β-bergamotane sesquiterpenoids, E-β-trans-5,8,11-trihydroxybergamot-9-ene (1) and β-trans-2β,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 3–5. Their structures were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were measured in vitro. Compound 4 exhibited potent activity against the U937 cell line with an IC₅₀ value of 4.2 μM.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.