Blood–brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis

Neurobiology of Disease

卷:20

Jeroen J.G. Geurts¹  Lisette Montagne²  Paul van der Valk³  Lars Bö³  Catharina M.P. Vos³  Frederik Barkhof³  Helga E. de Vries³  Elise S. van Haastert⁴ 

[1] Department of Molecular Cell Biology and Immunology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands;

[2] Graduate School Neurosciences Amsterdam, VU University Medical Center, Amsterdam, The Netherlands;

[3] Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands;

[4] Department of Radiology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands;

关键词: Multiple sclerosis;    Blood–brain barrier;    Basement membrane;    Postmortem MRI;    Leukocyte infiltration;    Virchow–Robin space;   

DOI  :  

来源: DOAJ

【 摘 要 】

Postmortem MRI-guided tissue sampling significantly enhances the yield of MS lesions in autopsy material, but so far it is unknown whether abnormalities concur with blood–brain barrier alterations. Here we sampled MS lesions with focal and diffuse abnormalities (diffusely abnormal white matter; DAWM) on MRI; both were coupled to the presence of MS lesions upon neuropathological examination. Extravascular distribution of fibrinogen, indicating BBB disturbance, was observed in so-called (p)reactive lesions that reflect discrete areas of microglial activation without demyelination within an otherwise normal appearing white matter. Leakage became more extensive in active demyelinating MS lesions to chronic inactive lesions. An enlargement of the perivascular (Virchow–Robin) space containing infiltrated leukocytes was associated with both DAWM and focal abnormalities on postmortem MRI. This study shows for the first time that in MS brain changes in the vasculature take place not only in focal lesions but also in DAWM as detected by postmortem MRI.

【 授权许可】

Unknown