Association between Non-Alcoholic Fatty Liver Disease and Chronic Kidney Disease: A Cross-Sectional Study

Journal of Clinical Medicine

卷:9

Akira Mitoro¹  Hitoshi Yoshiji¹  Naotaka Shimozato¹  Hideto Kawaratani¹  Yuki Tsuji¹  Kei Moriya¹  Takahiro Ozutsumi¹  Daisuke Kaya¹  Kosuke Kaji¹  Tadashi Namisaki¹  Masanori Furukawa¹  Yukihisa Fujinaga¹  Koh Kitagawa¹  Takemi Akahane¹  Hiroaki Takaya¹  Yasuhiko Sawada¹  Manabu Akahane² 

[1] Department of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan;

[2] Department of Health and Welfare Services, National Institute of Public Health, 2-3-6 Minami, Wako, Saitama 351-0197, Japan;

关键词: non-alcoholic fatty liver disease;    chronic kidney disease;    hepatic steatosis;    obesity;    hypertension;    hyperuricemia;   

DOI  :  10.3390/jcm9061635

来源: DOAJ

【 摘 要 】

It is unclear whether the link between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) is mediated by common risk factors. We aimed to elucidate the association between NAFLD and CKD using propensity score (PS)-matched analysis. We assessed 3725 Japanese individuals, excluding those with hepatitis B or C infection and men and women who consumed >30 and >20 g/day of alcohol, respectively. Of these, we enrolled 1097 Japanese subjects with NAFLD diagnosed by ultrasonography and 1097 PS-matched subjects without NAFLD. The prevalence of CKD was higher in subjects with NAFLD than in those without NAFLD before PS matching, but there was no significant difference between these groups in terms of CKD prevalence after PS matching. There was no difference in the prevalence of CKD between those with and without NAFLD in the subgroup analyses. Logistic regression analysis demonstrated that obesity, hypertension, and hyperuricemia were independent predictors of CKD, but NAFLD was not independently associated with CKD. In subjects with NAFLD, obesity, hypertension, and hyperuricemia were independent predictors of CKD. Thus, the link between NAFLD and CKD may be mediated by common risk factors. We recommend screening for CKD when patients with NAFLD have the aforementioned comorbidities.

【 授权许可】

Unknown