Amelioration of Hepatic Steatosis in Mice through Bacteroides uniformis CBA7346-Mediated Regulation of High-Fat Diet-Induced Insulin Resistance and Lipogenesis

Nutrients

Seong-Woon Roh¹  Hye-Seon Song¹  Moon-Ho Do²  Young-Do Nam²  Sang-Keun Ha²  Hye-Bin Lee²  Ho-Young Park²  Won-Hyong Chung²  Hyunjhung Jhun³ 

[1] Microbiology and Functionality Research Group, World institute of Kimchi, Gwangju 61755, Korea;Research Division of Food Functionality, Korea Food Research Institute, Wanju 55365, Korea;Technical Assistance Center, Korea Food Research Institute, Jeonju 55365, Korea;

关键词: Bacteroides uniformis;    high-fat diet;    non-alcoholic fatty liver disease;    hepatic steatosis;    lipid metabolism;   

DOI  :  10.3390/nu13092989

来源: DOAJ

【 摘 要 】

Dietary habits and gut microbiota play an essential role in non-alcoholic fatty liver disease (NAFLD) and related factors such as insulin resistance and de novo lipogenesis. In this study, we investigated the protective effects of Bacteroides uniformis CBA7346, isolated from the gut of healthy Koreans, on mice with high-fat diet (HFD)-induced NAFLD. Administration of B. uniformis CBA7346 reduced body and liver weight gain, serum alanine aminotransferase and aspartate aminotransferase levels, liver steatosis, and liver triglyceride levels in mice on an HFD; the strain also decreased homeostatic model assessment for insulin resistance values, as well as serum cholesterol, triglyceride, lipopolysaccharide, leptin, and adiponectin levels in mice on an HFD. Moreover, B. uniformis CBA7346 controlled fatty liver disease by attenuating steatosis and inflammation and regulating de novo lipogenesis-related proteins in mice on an HFD. Taken together, these findings suggest that B. uniformis CBA7346 ameliorates HFD-induced NAFLD by reducing insulin resistance and regulating de novo lipogenesis in obese mice.

【 授权许可】

Unknown