Tissue engineering approaches for the construction of a completely autologous tendon substitute

Indian Journal of Plastic Surgery

卷:41

Francesco Mazzoleni¹  Vindigni Vincenzo²  Dalla Vedova Alessandro²  Bassetto Franco²  Carolin Tonello³  Giovanni Abatangelo³ 

[1] ;

[2] Clinic of Plastic Surgery, Department of Medical and Surgical Specialities;

[3] Department of Histology, Microbiology and Medical Biotechnology, University of Padova, Padova, Italy;

关键词: biomaterials;    bioreactor;    mechanobiology;    tendon;    tissue engineering;   

DOI  :  10.1055/s-0039-1699225

来源: DOAJ

【 摘 要 】

Tissue engineering is a multidisciplinary field that involves the application of the principles and methods of engineering and life sciences towards i) the fundamental understanding of structure-function relationships in normal and pathological mammalian tissues and ii) the development of biological substitutes that restore, maintain or improve tissue function. The goal of tissue engineering is to surpass the limitations of conventional treatments based on organ transplantation and biomaterial implantation. The field of tendon tissue engineering is relatively unexplored due to the difficulty inin vitropreservation of tenocyte phenotype. Only recently has mechanobiology allowed us to gain a better understanding of the fundamental role ofin vitromechanical stimuli in maintaining the phenotype of tendinous tissue. This review analyzes the techniques used so far forin vitroregeneration of tendinous tissue.

【 授权许可】

Unknown