Control of cell differentiation by mechanical stress

Journal of Physical Fitness and Sports Medicine

Jong-Hoon Park¹  Takashi Ushida¹  Takayuki Akimoto¹ 

[1] Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo;

关键词: mechanotransduction;    muscle;    bone;    cartilage;    fat;    ligament;    tendon;    stem cells;    mechanobiology;    exercise;    vibration;   

DOI  :  10.7600/jpfsm.2.49

来源: DOAJ

【 摘 要 】

Cells sense mechanical force and their physical environment to change their fate and behavior through mechanotransduction. The mechanotransduction is, by translating mechanical forces and deformations into biochemical intracellular signaling, changing gene expressions and adjusting cellular and extracellular structure. Given that mechanosensitive signaling modulates cellular functions as diverse as proliferation and differentiation, such signaling is crucial for normal tissue development and homeostasis. Here we review current evidence for the mechanical regulation of cell differentiation, specifically in musculoskeletal tissues, such as skeletal muscle, fat, bone, and cartilage.

【 授权许可】

Unknown