Tissue engineering approaches for the construction of a completely autologous tendon substitute

Indian Journal of Plastic Surgery

关键词: Biomaterials;    bioreactor;    mechanobiology;    tendon;    tissue engineering;   

DOI  :  

来源: DOAJ

【 摘 要 】

Tissue engineering is a multidisciplinary field that involves the application of the principles and methods of engineering and life sciences towards i) the fundamental understanding of structure-function relationships in normal and pathological mammalian tissues and ii) the development of biological substitutes that restore, maintain or improve tissue function. The goal of tissue engineering is to surpass the limitations of conventional treatments based on organ transplantation and biomaterial implantation. The field of tendon tissue engineering is relatively unexplored due to the difficulty in in vitropreservation of tenocyte phenotype. Only recently has mechanobiology allowed us to gain a better understanding of the fundamental role of in vitromechanical stimuli in maintaining the phenotype of tendinous tissue. This review analyzes the techniques used so far for in vitroregeneration of tendinous tissue.

【 授权许可】

Unknown