Disrupted Cerebellar-Default Mode Network Functional Connectivity in Major Depressive Disorder With Gastrointestinal Symptoms

Frontiers in Cellular Neuroscience

卷:16

Yudan Ding¹  Haohao Yan¹  Yangpan Ou¹  Xiaoya Fu¹  Meiqi Yan¹  Wenbin Guo²  Feng Liu⁴  Huabing Li⁵ 

[1] Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China;

[2] Department of Psychiatry, The Third People’s Hospital of Foshan, Foshan, China;

[3] Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China;

[4] Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China;

[5] Hunan Key Laboratory of Children’s Psychological Development and Brain Cognitive Science, Changsha, China;

关键词: major depressive disorder;    gastrointestinal symptoms;    functional magnetic resonance imaging;    cerebellum;    default mode network;   

DOI  :  10.3389/fncel.2022.833592

来源: DOAJ

【 摘 要 】

Gastrointestinal (GI) symptoms are one of the common somatic symptoms presented in patients with major depressive disorder (MDD). Higher frequency of GI symptoms and higher GI symptom burden were linked to greater depression severity and increased risk of suicide ideation. However, few studies have explored the underlying mechanisms of GI symptoms in MDD. Based on previous studies, the cerebellar-DMN circuits may play a potentially critical role in GI symptoms comorbid with depression. Fifty-two first-episode drug-naive patients with MDD (35 with GI symptoms and 17 without GI symptoms) and 28 matched healthy controls were recruited in the current study and underwent resting-state functional magnetic resonance imaging scan. Cerebellar seed-based functional connectivity maps were established. Relative to depressed patients without GI symptoms, significantly increased cerebellar-anterior default mode network (DMN) connectivities were found in those with GI symptoms. Both increased and decreased functional connectivities were found between cerebellum and posterior DMN in patients with GI symptoms compared with those without GI symptoms and healthy controls. Moreover, the right Crus I - right superior temporal gyrus connectivity value was related to severity of GI symptoms and depression in all patients with MDD. The support vector machine analysis demonstrated a satisfactory classification accuracy (89%) of the disrupted cerebellar-DMN connectivities for correctly identifying MDD patients with GI symptoms. These results revealed the possible neural mechanisms for the involvement of cerebellar-DMN circuits in GI symptoms co-occurred with MDD.

【 授权许可】

Unknown