Disrupted Regional Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest

Frontiers in Psychiatry

Jingping Zhao¹  Meiqi Yan¹  Jindong Chen¹  Yanqing Tang²  Wenbin Guo³  Huabing Li⁴  Feng Liu⁵  Renzhi Huang⁶ 

[1] Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China;Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China;Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, China;Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China;Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China;Hunan Key Laboratory of Children's Psychological Development and Brain Cognitive Science, Changsha, China;

关键词: major depressive disorder;    regional homogeneity;    gastrointestinal symptoms;    magnetic resonance imaging;    resting state;   

DOI  :  10.3389/fpsyt.2021.636820

来源: DOAJ

【 摘 要 】

Background: Gastrointestinal (GI) symptoms are prominent in patients with major depressive disorder (MDD). Previous studies have reported brain structural and functional changes in both MDD and digestive system diseases but it remains unclear whether MDD patients with GI symptoms have brain imaging changes.Methods: We recruited 35 MDD patients with GI symptoms, 17 MDD patients without GI symptoms and 28 age-, gender-, and education-matched healthy controls. All participants were scanned by resting-state functional magnetic resonance imaging (fMRI). Imaging data were analyzed with regional homogeneity (ReHo).Results: The GI group showed higher total HRSD-17 scores, anxiety/somatization, weight loss, and sleep disturbance scores compared to the non-GI group. We found increased ReHo in the right inferior parietal gyrus (IPL), bilateral supplementary motor area (SMA), bilateral cerebellum Crus II, left inferior frontal gyrus (IFG), and bilateral superior medial frontal cortex (SMFC) and decreased ReHo in the right posterior cingulate cortex (PCC), bilateral cuneus, and left middle occipital gyrus (MOG) in patients with GI symptoms relative to the HCs. The GI group showed higher ReHo values in the bilateral precuneus than the non-GI group.Conclusion: MDD patients with GI symptoms showed a greater severity of symptoms than MDD patients without GI symptoms, particularly in terms of anxiety/somatization, weight loss, and sleep disturbances. Increased activity in the default-mode network might be associated with GI symptoms in MDD patients.

【 授权许可】

Unknown