Default mode network alterations during implicit emotional faces processing in first-episode, treatment-naive major depression patients

Frontiers in Psychology

Huqing Shi¹ 

关键词: major depressive disorder;    emotional faces processing;    functional magnetic resonance imaging;    default mode network;    independent component analysis;   

DOI  :  10.3389/fpsyg.2015.01198

学科分类：心理学（综合）

来源: Frontiers

【 摘 要 】

Previous studies have focused on resting-state default mode network (DMN) alterations in the development and maintenance of depression; however, only a few studies have addressed DMN changes during task-related processing and their results are inconsistent. Therefore, we explored DMN patterns in young adult patients with first-episode, treatment-naïve major depressive disorder (MDD) performing an implicit emotional processing task. Patients with MDD (N = 29) and healthy controls (N = 33) were subjected to functional magnetic resonance imaging (fMRI) at rest and while performing a gender judgment task. Group independent component analysis (ICA) was used to identify DMN component under task state for both groups. The DMN of participants with MDD had decreased functional connectivity in bilateral prefrontal areas compared to controls. Right prefrontal gyrus connectivity for MDD patients correlated negatively with scores on maladaptive scales of the Cognitive Emotion Regulation Questionnaire (CERQ). Our findings suggest that depressed people have altered DMN patterns during implicit emotional processing, which might be related to impaired internal monitoring and emotional regulation ability.

【 授权许可】

CC BY