Visible light-promoted enantioselective aerobic oxidation of pyrazolones by phase transfer catalysis

Green Synthesis and Catalysis

卷:3

Shuaifei Wang¹  Yifan Chen²  Ke Wang³  Mingming Lian⁴  Yawei Zhang⁴  Jie Liu⁴  Lizhen Fang⁴  Tao Zhang⁴  Yakun Wang⁴ 

[1] Corresponding author.;

[2] Department of Pharmaceutics, Daqing Campus, Harbin Medical University, Daqing, Heilongjiang, 163319, China;

[3] School of Medical Engineering, Xinxiang Medical University, Xinxiang, Henan, 453003, China;

[4] School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, 453003, China;

关键词: Aerobic oxidation;    Pyrazolone;    Visible light;    Phase transfer catalysis;    Cinchona alkaloid;   

DOI  :  

来源: DOAJ

【 摘 要 】

An efficient and enantioselective aerobic oxidation of 4-substituted pyrazolones has been developed by phase transfer catalysis. Using visible light as the driving force and O2 (in air) as the oxidant, broad scopes (38 examples) of pyrazolones bearing an oxygen-attached carbon stereocenter at C-4 position were obtained in high yields (up to 98%) and excellent enantioselectivities (up to 93% ee) under mid conditions. The ready availability of catalyst, ease of operation, and low-cost and eco-friendly nature highlighted the practical utility of this visible light-promoted enantioselective aerobic oxidation.

【 授权许可】

Unknown