Interleukin-22: a potential therapeutic target in atherosclerosis

Molecular Medicine

卷:27

Peng Huang¹  Jin-Wen Luo¹  Jian Liu¹  Huan Yang²  Yuan Hu³ 

[1] Department of Cardio-Thoracic Surgery, Hunan Children’s Hospital;

[2] Department of Respiratory Medicine, Hunan Provincial People’s Hospital;

[3] Department of Ultrasound Medicine, Hunan Children’s Hospital;

关键词: Atherosclerosis;    IL-22;    Inflammatory response;    Cytokine;    Cholesterol metabolism;   

DOI  :  10.1186/s10020-021-00353-9

来源: DOAJ

【 摘 要 】

Abstract Background Atherosclerosis is recognized as a chronic immuno-inflammatory disease that is characterized by the accumulation of immune cells and lipids in the vascular wall. In this review, we focus on the latest advance regarding the regulation and signaling pathways of IL-22 and highlight its impacts on atherosclerosis. Main body IL-22, an important member of the IL-10 family of cytokines, is released by cells of the adaptive and innate immune system and plays a key role in the development of inflammatory diseases. The binding of IL-22 to its receptor complex can trigger a diverse array of downstream signaling pathways, in particular the JAK/STAT, to induce the expression of chemokines and proinflammatory cytokines. Recently, numerous studies suggest that IL-22 is involved in the pathogenesis of atherosclerosis by regulation of VSMC proliferation and migration, angiogenesis, inflammatory response, hypertension, and cholesterol metabolism. Conclusion IL-22 promotes the development of atherosclerosis by multiple mechanisms, which may be a promising therapeutic target in the pathogenesis of atherosclerosis.

【 授权许可】

Unknown