Intestinal Flora as a Potential Strategy to Fight SARS-CoV-2 Infection

Frontiers in Microbiology

卷:11

Li-Hong He²  Long-Fei Ren²  Yong-Na Wu²  Xun Li²  Lei Zhang²  Jun-Feng Li³ 

[1] Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China;

[2] Key Laboratory of Biological Therapy and Regenerative Medicine Transformation Gansu Province, Lanzhou, China;

[3] The Department of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou, China;

[4] The First Clinical Medical College, Lanzhou University, Lanzhou, China;

关键词: COVID-19;    SARS-CoV-2;    intestinal flora;    gut-lung axis;    immunity;    SCFAs;   

DOI  :  10.3389/fmicb.2020.01388

来源: DOAJ

【 摘 要 】

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly worldwide, seriously endangering human health. In addition to the typical symptoms of pulmonary infection, patients with COVID-19 have been reported to have gastrointestinal symptoms and/or intestinal flora dysbiosis. It is known that a healthy intestinal flora is closely related to the maintenance of pulmonary and systemic health by regulating the host immune homeostasis. Role of the “gut-lung axis” has also been well-articulated. This review provides a novel suggestion that intestinal flora may be one of the mediators of the gastrointestinal responses and abnormal immune responses in hosts caused by SARS-CoV-2; improving the composition of intestinal flora and the proportion of its metabolites through probiotics, and personalized diet could be a potential strategy to prevent and treat COVID-19. More clinical and evidence-based medical trials may be initiated to determine the strategy.

【 授权许可】

Unknown