Regulation of SARS-CoV-2 infection by diet-modulated gut microbiota

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Vivian Tieu¹  Jun Ling¹  Sedra Tibi¹ 

[1] Department of Medical Education, California University of Science and Medicine, School of Medicine, Colton, CA, United States;

关键词: SARS-CoV-2;    COVID-19;    innate and adaptive immune system;    microbiota;    gut-lung axis;    comorbidity;    non-Western diet;   

DOI  :  10.3389/fcimb.2023.1167827

 received in 2023-02-22, accepted in 2023-06-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection has claimed millions of lives since late 2019, yet there are still many unexplored areas in its pathogenesis and clinical outcomes. COVID-19 is a disease that can affects multiple systems, some of which are overlapped with those modulated by gut microbiota, especially the immune system, thus leading to our concentration on analyzing the roles of microbiota in COVID-19 pathogenesis through the gut-lung axis. Dysbiosis of the commensal intestinal microbes and their metabolites (e.g., SCFAs) as well as the expression and activity of ACE2 in the gut could influence the host’s immune system in COVID-19 patients. Moreover, it has been known that the elderly and individuals diagnosed with comorbidities (e.g., hypertension, type 2 diabetes mellitus, cardiovascular disease, etc.) are more susceptible to gut flora alterations, SARS-CoV-2 infection, and death. Thus, in this review we will focus on analyzing how the gut microbiota regulates the immune system that leads to different responses to SARS-CoV-2 infection. Since diet is a major factor to modulate the status of gut microbiota, dietary influence on COVID-19 pathogenesis will be also discussed, aiming to shed light on how diet-modulated gut microbiota regulates the susceptibility, severity, and treatment of SARS-CoV-2 infection.

【 授权许可】

Unknown   
Copyright © 2023 Tieu, Tibi and Ling