Unraveling the Interconnection Patterns Across Lung Microbiome, Respiratory Diseases, and COVID-19

Frontiers in Cellular and Infection Microbiology

Elisavet Stavropoulou¹  Chrissoula Voidarou²  Eugenia Bezirtzoglou³  Theodoros Konstantinidis³  Theocharis Konstantinidis⁴  Christina Tsigalou⁴  Konstantia Kantartzi⁵ 

[1]CHUV (Centre HospitalierUniversitaire Vaudois), Lausanne, Switzerland

[2]Department of Infectious Diseases, Central Institute, Valais Hospital, Sion, Switzerland

[3]Department of Public Health P.U., Arta, Greece

[4]Laboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece

[5]Laboratory of Microbiology, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece

[6]Nephrology Clinic, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece

关键词: lung microbiome;    lung-gut axis;    lung in health and disease;    lung;    microbiota;    COVID-19;    SARS-CoV-2;    lung immunity;   

DOI  :  10.3389/fcimb.2020.619075

来源: Frontiers

【 摘 要 】

Albeit the lungs were thought to be sterile, recent scientific data reported a microbial microbiota in the lungs of healthy individuals. Apparently, new developments in technological approachesincluding genome sequencing methodologies contributed in the identification of the microbiota and shed light on the role of the gut and lung microbiomes in the development of respiratory diseases. Moreover, knowledge of the human microbiome in health may act as a tool for evaluating characteristic shifts in the case of disease. This review paper discusses the development of respiratory disease linked to the intestinal dysbiosis which influences the lung immunity and microbiome. The gastrointestinal–lung dialogue provides interesting aspects in the pathogenesis of the respiratory diseases. Lastly, we were further interested on the role of this interconnection in the progression and physiopathology of newly emergedCOVID-19.

【 授权许可】

CC BY