New Cembranolides from the Dongsha Atoll Soft Coral Lobophytum durum

Marine Drugs

卷:9

关键词: soft coral;    Lobophytum durum;    cytotoxicity;    antiviral activity;   

DOI  :  10.3390/md9081307

来源: DOAJ

【 摘 要 】

Chemical investigations of the Dongsha Atoll soft coral Lobophytum durum resulted in the isolation of five new cembranolides, durumolides M–Q (1–5). The structures of compounds 1–5 were characterized by the interpretation of extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED50 of 3.8 μg/mL. Moreover, compound 5 showed significant antiviral activity against human cytomegalovirus with an IC50 of 5.2 μg/mL.

【 授权许可】

Unknown