New Cembranolides from the Dongsha Atoll Soft Coral Lobophytum durum

Marine Drugs

Shi-Yie Cheng²  Pei-Wen Chen²  Hwa-Pyng Chen²  Shang-Kwei Wang¹ 

[1] Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan;Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mails:

关键词: soft coral;    Lobophytum durum;    cytotoxicity;    antiviral activity;   

DOI  :  10.3390/md9081307

来源: mdpi

【 摘 要 】

Chemical investigations of the Dongsha Atoll soft coral Lobophytum durum resulted in the isolation of five new cembranolides, durumolides M–Q (1–5). The structures of compounds 1–5 were characterized by the interpretation of extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED₅₀ of 3.8 μg/mL. Moreover, compound 5 showed significant antiviral activity against human cytomegalovirus with an IC₅₀ of 5.2 μg/mL.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.