Evaluation of absorption and depletion of florfenicol in European seabass Dicentrarchus labrax

Veterinary Medicine and Science

卷:7

Adriana Triga¹  Pantelis Katharios¹  Chrysanthi Nikoloudaki²  Dimitra Kogiannou²  George Rigos² 

[1] Hellenic Centre for Marine Research (HCMR) Institute of Marine Biology, Biotechnology and Aquaculture (IMBBC), Former American Base of Gournes Heraklion, Crete Greece;

[2] Hellenic Centre for Marine Research (HCMR), Institute of Marine Biology, Biotechnology and Aquaculture (IMBBC) Anavyssos Attika Greece;

关键词: florfenicol;    florfenicol amine;    muscle plus skin;    pharmacokinetics;    withdrawal time;   

DOI  :  10.1002/vms3.415

来源: DOAJ

【 摘 要 】

Abstract The pharmacokinetic properties and residue elimination of florfenicol (FLO) and its amine were investigated in European seabass Dicentrarchus labrax at 24°C. The trial mainly included analysis of FLO in plasma after a single dose dietary administration of 10 mg/kg and in muscle plus skin following a multiple dosing (10 mg kg−1 day−1 for 7 days) to estimate pharmacokinetics and residue depletion, respectively. The maximum plasma concentration of FLO was measured to be 1.64 μg/ml, 4 hr post administration. The elimination half‐life (t1/2b) and the area under the concentration‐time curve extrapolated to infinity (AUC0‐∞) were calculated to be 13.0 hr and 34.7 μg h−1 ml−1, respectively. Withdrawal times of FLO and its amine were calculated to be 46.3 degree‐days, indicating a fast removal from the edible tissues of treated European seabass. Overall, FLO can be considered as a potentially efficient antibacterial agent for farmed European seabass provided that additional efforts will be devoted towards its in vitro and clinical efficacy.

【 授权许可】

Unknown