Pharmacokinetics of a Florfenicol-Tylosin Combination after Intravenous and Intramuscular Administration to Beagle Dogs

Journal of Veterinary Medical Science

Jong-Choon KIM²  Seung-Chun PARK³  Eun-Young KIM¹  Elias GEBRU³  Joong-Su LEE³ 

[1] Gyeongbuk Veterinary Service Laboratory;Animal Medical Center, College of Veterinary Medicine, Chonnam National University;Laboratory of Applied Pharmacokinetics & Pharmacodynamics, College of Veterinary Medicine, Kyungpook National University

关键词: canine;    combination;    florfenicol;    pharmacokinetics;    tylosin;   

DOI  :  10.1292/jvms.10-0243

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(26)Cited-By(2)A pharmacokinetic study of a commercial florfenicol-tylosin (2:1) combination product was conducted in six beagle dogs after intravenous (IV) and intramuscular (IM) administration at doses of 10 mg/kg (florfenicol) and 5 mg/kg (tylosin). Serum drug concentrations were determined by a validated high performance liquid chromatography (HPLC) using UV detection. A rapid and nearly complete absorption of both drugs with a mean IM bioavailability of 103.9% (florfenicol) and 92.6% (tylosin), prolonged elimination half-life, and high tissue penetration with steady state volume of distribution of 2.63 l/kg (florfenicol) and 1.98 l/kg (tylosin) were observed. Additional studies, including pharmacodynamic and toxicological evaluation are required before recommendations can be made regarding the clinical application of the product in dogs.

【 授权许可】

Unknown