Comparative Pharmacokinetics of Tylosin or Florfenicol after a Single Intramuscular Administration at Two Different Doses of Tylosin-Florfenicol Combination in Pigs

Journal of Veterinary Medical Science

Eun-Hee KANG²  Mi-Hee KIM²  Jong-Hwan LIM¹  Jae-Young CHOI²  Seung-Chun PARK²  Zhi-Qiang CHANG²  Hyo-In YUN¹  Mi-Hyun HWANG²  Elias GEBRU² 

[1] College of Veterinary Medicine, Chungnam National University;College of Veterinary Medicine, Kyungpook National University

关键词: florfenicol;    pharmacokinetics;    tylosin;   

DOI  :  10.1292/jvms.70.99

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(18)Cited-By(4)Clinical pharmacokinetic profiles were investigated following intramuscular (i.m.) administration to pigs with a commercial tylosin-florfenicol combination product at a dose of 2.5 mg/kg tylosin and 5 mg/kg florfenicol or 10 mg/kg tylosin and 20 mg/kg florfenicol. The quantitation limit (QL) of florfenicol was 0.1 μg/ml, the inter-day and intra-day precision (CV%) were both beow 10%. The quantitation limit (QL) of tylosin was 0.05 μg/mL. The pharmacokinetic characteristics after i.m. doses were fitted by a one compartment open model. A fourfold decrease in the normal dose of each drug (20 mg/kg to 5 mg/kg for florfenicol, and 10 mg/kg to 2.5 mg/kg for tylosin) resulted in a corresponding two fold decrease in each drug of the maximum plasma concentration (Cmax) and the area under curve (AUC) values.

【 授权许可】

Unknown