Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines

Cellular & Molecular Biology Letters

卷:26

Songou Zhang¹  Xiaozhen Chen¹  Jian Fang¹  Xuerong Chen²  Meikai Chen²  Yifan Xu²  Wenqing Liang³ 

[1] College of Medicine, Shaoxing University;

[2] Department of Orthopaedics, Shaoxing People’s Hospital, The First Affiliated Hospital of Shaoxing University;

[3] Department of Orthopaedics, Zhoushan Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University;

关键词: Angiogenesis;    Cancer-associated fibroblasts;    Immunosuppression;    Metastasis;    Mesenchymal stem cells;   

DOI  :  10.1186/s11658-020-00246-5

来源: DOAJ

【 摘 要 】

Abstract Mesenchymal stem cells (MSCs) show homing capacity towards tumor sites. Numerous reports indicate that they are involved in multiple tumor-promoting processes through several mechanisms, including immunosuppression; stimulation of angiogenesis; transition to cancer-associated fibroblasts; inhibition of cancer cell apoptosis; induction of epithelial–mesenchymal transition (EMT); and increase metastasis and chemoresistance. However, other studies have shown that MSCs suppress tumor growth by suppressing angiogenesis, incrementing inflammatory infiltration, apoptosis and cell cycle arrest, and inhibiting the AKT and Wnt signaling pathways. In this review, we discuss the supportive and suppressive impacts of MSCs on tumor progression and metastasis. We also discuss MSC-based therapeutic strategies for cancer based on their potential for homing to tumor sites.

【 授权许可】

Unknown