The role of cancer-associated fibroblasts in esophageal cancer

Journal of Translational Medicine

Review

Yufeng Cheng¹  Guangyu Zhang¹  Jiangfeng Wang¹  Lu Wang¹  Jianbo Wang¹  Xiaochen Huang¹ 

[1] Department of Radiation Oncology, Qilu Hospital of Shandong University, No 107 West Wenhua Road, 250012, Jinan, People’s Republic of China;

关键词: Esophageal cancer;    Cancer-associated fibroblasts;    Carcinogenesis;    Progression;    Metastasis;    Prognosis;    Treatment;   

DOI  :  10.1186/s12967-016-0788-x

 received in 2015-08-03, accepted in 2016-01-17,  发布年份 2016

来源: Springer

【 摘 要 】

Fibroblasts are known as critical stromal cells in wound healing by synthesizing extracellular matrix and collagen. A subpopulation of them is called cancer-associated fibroblasts (CAFs), because their production of proteins participated in various biological activities including tumor cell proliferation, invasion and metastasis. Currently some studies shed light on their role in esophageal cancer which was an aggressive cancer with a dismal survival and high rate of metastasis. Thus, to find cures for it relies on elucidating the epithelial-fibroblasts crosstalk. Herein, we reviewed the present knowledge of the CAFs’ role in esophageal premalignant condition, cancer initiation, progression, metastasis and prognosis prediction and further provided some insights into its clinical application.

【 授权许可】

CC BY   
© Wang et al. 2016