Maternal hepatitis B surface antigen carrier status increased the incidence of gestational diabetes mellitus

BMC Infectious Diseases

卷:19

Songxu Peng¹  Xiaofang Lin¹  Yukai Du¹  Zhihua Wan¹  Xiu Li¹ 

[1] Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology;

关键词: Gestational diabetes mellitus;    Hepatitis B virus infection;    Hepatitis B surface antigen;    Viral load;   

DOI  :  10.1186/s12879-019-3749-1

来源: DOAJ

【 摘 要 】

Abstract Background The relationship between chronic hepatitis B virus (HBV) infection with gestational diabetes mellitus (GDM) remains unclear. This study aimed to identify the association between maternal HBsAg-positive status and GDM. Methods A retrospective cohort study was performed on the pregnant women who delivered from June 2012 to May 2016 at Wuhan Medical Care Center for Women and Children, Wuhan, China. We compared the incidence of GDM between HBsAg-positive pregnant women and HBsAg-negative controls. A multivariate regression model was used to measure the independent association between maternal HBsAg carrier and the risk of developing GDM. Results In total, 964 HBsAg-positive pregnant women and 964 HBsAg-negative women were included into the study. We observed maternal HBsAg carrier (OR 1.47, 95% CI 1.06–2.03), age (OR 1.05, 95% CI 1.00–1.10) and family history of diabetes (OR 3.97, 95% CI 2.05–7.67) had an independent risk for GDM in multivariable logistical regression model. However, no significant association was found between HBeAg carrier status, other HBV markers or viral load in pregnancy and the incidence of GDM. Conclusions Our results indicated that maternal HBsAg carriage is an independent risk factor for GDM, but viral activity indicated by HBeAg status and viral load is not the main reason for this phenomenon. Further studies are warranted to clarify the possible mechanisms behind such association of HBV infection and the additional risk of GDM.

【 授权许可】

Unknown