Association between maternal hepatitis B virus carrier and gestational diabetes mellitus: a retrospective cohort analysis

Virology Journal

Xiuzi Li¹  Wanchang Yin¹  Yilin Yang¹  Ruirui Li¹  Guixian Chen¹  Dunjin Chen²  Fang He²  Bingjun Chen²  Jiangnan Xie³ 

[1] Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;Key Laboratory for Major Obstetric Diseases of Guangdong Province, Guangzhou, China;Key Laboratory for Major Obstetric Diseases of Guangdong Province, Guangzhou, China;

关键词: Hepatitis B surface antigen;    Deoxyribonucleic acid load;    Gestational diabetes mellitus;   

DOI  :  10.1186/s12985-021-01691-0

来源: Springer

【 摘 要 】

IntroductionGiven that many pregnant women have chronic hepatitis B virus (HBV) infection and that gestational diabetes mellitus (GDM) is linked to poor maternal and neonatal outcomes, we looked into the relationship between the hepatitis B surface antigen (HBsAg) and GDM to see if a high HBV DNA load is linked to a higher risk of GDM in chronic maternal HBsAg carriers.Materials and methodsOur study included 39,539 pregnant women who gave birth at the Third Affiliated Hospital of Guangzhou Medical University in Guangzhou, China, between January 1, 2009, and December 31, 2019. The patients were divided into two groups: HBsAg negative (36,500) and positive (3039). The viral load levels of 1250 HBsAg-positive women who had tested their HBV DNA load during pregnancy were separated into three groups. We utilized univariate and multivariable logistical regression analysis to determine the relationship between maternal chronic HBsAg carrier and GDM.ResultsBeing HBsAg positive was discovered to be an independent risk factor for GDM.Pre-pregnancy Obesity and advanced age were linked to an increased incidence of GDM. Those with a high HBV DNA load (> 106 IU/mL) had a higher risk of GDM than HBsAg-positive women with a low viral load (< 103 IU/mL). Pre-eclampsia and intrahepatic cholestasis of pregnancy (ICP) appeared to be more common in HBsAg-positive women than in uninfected women.ConclusionsBeing HBsAg positive, advanced age, and pre-pregnancy obesity were all revealed to be independent risk factors for GDM in our study. In HBsAg carrier, pregnant women, a high HBV DNA burden was linked to a greater risk of GDM. Furthermore, being an HBsAg carrier during pregnancy raised the risk of ICP and pre-eclampsia.

【 授权许可】

CC BY