Neddylation-dependent protein degradation is a nexus between synaptic insulin resistance, neuroinflammation and Alzheimer’s disease

Translational Neurodegeneration

Shaobo Jia¹  Alexander Dityatev²  Tingting Li³  Robert Ahrends⁴  Rajeev Raman⁵  Alessandro Dario Confettura⁵  Mohamed Rafeet Ammar⁵  Eleonora Cuboni⁵  PingAn Yuanxiang⁵  Anna Karpova⁶  Guilherme M. Gomes⁶  Michael R. Kreutz⁷  Katarzyna M. Grochowska⁸ 

[1] German Center for Neurodegenerative Diseases (DZNE), 39120, Magdeburg, Germany;German Center for Neurodegenerative Diseases (DZNE), 39120, Magdeburg, Germany;Center for Behavioral Brain Sciences, Otto Von Guericke University, 39120, Magdeburg, Germany;Medical Faculty, Otto-von-Guericke University, 39120, Magdeburg, Germany;Leibniz-Institut Für Analytische Wissenschaften-ISAS-e.V., 44227, Dortmund, Germany;Leibniz-Institut Für Analytische Wissenschaften-ISAS-e.V., 44227, Dortmund, Germany;Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090, Wien, Austria;RG Neuroplasticity, Leibniz-Institute for Neurobiology, 39118, Magdeburg, Germany;RG Neuroplasticity, Leibniz-Institute for Neurobiology, 39118, Magdeburg, Germany;Center for Behavioral Brain Sciences, Otto Von Guericke University, 39120, Magdeburg, Germany;RG Neuroplasticity, Leibniz-Institute for Neurobiology, 39118, Magdeburg, Germany;German Center for Neurodegenerative Diseases (DZNE), 39120, Magdeburg, Germany;Center for Behavioral Brain Sciences, Otto Von Guericke University, 39120, Magdeburg, Germany;Leibniz Group ‘Dendritic Organelles and Synaptic Function’, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany;RG Neuroplasticity, Leibniz-Institute for Neurobiology, 39118, Magdeburg, Germany;Leibniz Group ‘Dendritic Organelles and Synaptic Function’, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany;

关键词: Metabolic syndrome;    Alzheimer's disease;    Neddylation;    Cullins;    MLN-4924;    Insulin;    IRS1;    Amyloid-β;    TNFα;   

DOI  :  10.1186/s40035-021-00277-8

来源: Springer

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