会议论文详细信息
26th IUPAP Conference on Computational Physics | |
Aggregation process of Aβ1-40 with non-Aβ amyloid component of α-synuclein | |
物理学;计算机科学 | |
Eugene, Cindie^1 ; Mousseau, Normand^1 | |
Département de Physique and Groupe de Recherche sur les Protéines Membranaires, Université de Montréal, Succursale Centre-ville, C.P. 6128, Montréal | |
QC, Canada^1 | |
关键词: Aggregation process; Alzheimer's disease; Amyloid fibers; Amyloid fibril; Ionic interaction; Parkinson's disease; Replica-exchange molecular dynamics simulations; Secondary structures; | |
Others : https://iopscience.iop.org/article/10.1088/1742-6596/640/1/012008/pdf DOI : 10.1088/1742-6596/640/1/012008 |
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学科分类:计算机科学(综合) | |
来源: IOP | |
【 摘 要 】
Many neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, are characterized by the presence of amyloid fibers. Recently, attention has turned from the fibers to the early stages of oligomerization where toxicity could be highest. Here, we focus on the interactions between non-Aβ amyloid component of a-synuclein (NAC) and Aβ1-40, two proteins found in amyloid fibrils associated with Alzheimer's disease. We combine the coarse-grained OPEP potential with a Hamiltonian and temperature replica exchange molecular dynamics simulation (HT-REMD) to identify mechanisms leading to the formation of secondary structures promoting fibrillation. We observe that the propensity to form beta-sheet remains the same for Aβ1-40whereas is decreases significantly for NAC. In particular, the 25-35 region of Aβ1-40is a significant area of secondary structure stabilization with NAC. The ionic interactions between salt-bridge D23 and K28 in Aβ1-40and K20 and E23 in NAC of the heterogeneous dimer are consistent with the salt-bridges found in NAC and Aβ1-40homogenous dimers and allow us to see that these interactions don't necessarily dominate the interchain stabilizations. Our numerical simulation also show the formation of interaction between the early oligomer of NAC and Aβ1-40.【 预 览 】
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