Primary Toxoplasma gondii infection-associated with hemophagocytic syndrome in a man with HIV infection: a case report

BMC Infectious Diseases

Yongfeng Liu¹  Ying Wen²  Ying Zhou² 

[1] BGI Pathogenesis Pharmaceutical TechnologyBGI-Shenzhen, Shenzhen, Guangdong Province, China;Department of Infectious Diseases, The First Affiliated Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, 110001, Shenyang, Liaoning Province, China;

关键词: Toxoplasma gondii;    Hemophagocytic syndrome;    Human immunodeficiency virus;    Metagenomic next-generation sequencing;   

DOI  :  10.1186/s12879-021-07022-6

来源: Springer

【 摘 要 】

BackgroundReactivation of latent Toxoplasma gondii (T. gondii) infection is more common than primary infection in patients with human immunodeficiency virus (HIV). We report a rare case of primary T. gondii infection-associated hemophagocytic syndrome (HPS).Case presentationA man with HIV infection presented with fever, dyspnea and pancytopenia. He was diagnosed with primary T. gondii infection by the seroconversion from single-positive IgM antibody to double-positive IgM and IgG antibody. Metagenomic next-generation sequencing (mNGS) of a plasma sample yielded high reads of T. gondii DNA. He responded well to combined anti-Toxoplasma medicines and glucocorticoid treatment.ConclusionsIn patients with HPS and positive T. gondii IgM antibody, mNGS analysis of a peripheral blood sample is helpful in diagnosing disseminated T. gondii infection. The dynamic changes by serological detection for IgM and IgG of T. gondii further supported the inference that the patient has experienced a primary T. gondii infection.

【 授权许可】

CC BY