Gastrointestinal manifestations of Talaromyces marneffei infection in an HIV-infected patient rapidly verified by metagenomic next-generation sequencing: a case report

BMC Infectious Diseases

Yongfeng Liu¹  Ying Wen²  Ying Zhou² 

[1] BGI PathoGenesis Pharmaceutical Technology, BGI-Shenzhen, Shenzhen, Guangdong Province, China;Department of Infectious Diseases, The First Affiliated Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, 110001, Shenyang, Liaoning Province, China;

关键词: Human immunodeficiency virus;    Talaromyces marneffei;    Gastrointestinal involvement;    Metagenomic next-generation sequencing;   

DOI  :  10.1186/s12879-021-06063-1

来源: Springer

【 摘 要 】

BackgroundThe manifestation of Talaromyces marneffei infection in some HIV-infected patients may be atypical. Cases with gastrointestinal involvement have rarely been reported. It is hard to make a diagnosis when patients are lacking the characteristic rash and positive blood culture.Case presentationHere, we described a patient living with HIV who complained of fever and abdominal pain, and was rapidly diagnosed with Talaromyces marneffei infection by metagenomic next-generation sequencing (mNGS) using formalin-fixation and paraffin-embedded (FFPE) samples of omentum majus tissue. We also reviewed reported related cases.ConclusionsTalaromyces marneffei is an unusual cause of clinical presentations involving obvious abdominal pain and lower gastrointestinal bleeding, but can be included in the differential diagnosis. As an important diagnostic tool, the significance of mNGS using FFPE samples of lesions provides a more targeted diagnosis.

【 授权许可】

CC BY