The role of drugs in HIV prevention

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Kembaren, T.^1,2

Division of Infectious and Tropical Diseases, Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^1

Haji Adam Malik General Hospital, Medan, Indonesia^2

关键词: Antiretrovirals;    Behavioral changes;    HIV transmission;    Human immunodeficiency virus;    Opportunistic infections;    Prevention strategies;    Transmission rates;    Viral replication;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012088/pdf
DOI  :  10.1088/1755-1315/125/1/012088

来源: IOP

【 摘 要 】

WHO reports 36.7 million people are living with Human Immunodeficiency Virus (HIV) worldwide by 2016 with about 1.8 million new infections each year. It will be a specific health problem for the world in both developed and developing countries so it is necessary strategies to reduce HIV transmission to the community. HIV transmission in people with risk factors is largely determined by the amount of virus in the blood of people who are the source of infection. Antiretroviral (ARV) therapy has long been used in HIV patients, which serves to suppress viral replication so that the patient's immunity increases; opportunistic infections are resolved and prolong the lifespan and lower transmission rates. In the HIV Prevention Trials Network (HPTN) study 052 there was a 96% reduction in transmission in earlier antiretroviral. ARV is also used in the prevention of transmission in people exposed to HIV virus that is Postexposure Prophylaxis as well as in people at risk before exposure (Pre-exposure Prophylaxis). Three prevention strategies with the provision of ARV is expected to be guided as a means of prevention of transmission in addition to behavioral changes has long been declared since the beginning of the HIV epidemic.