Therapeutical interference with the epigenetic landscape of germ cell tumors: a comparative drug study and new mechanistical insights

Clinical Epigenetics

Peter Albers¹  Margaretha A. Skowron²  Melanie R. Müller²  Alexa Stephan²  Daniel Nettersheim²  Aaron Burmeister²  Gamal A. Wakileh³  Patrick Petzsch⁴  Karl Köhrer⁴  Felix Bremmer⁵ 

[1] Department of Urology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany;Department of Urology, Urological Research Laboratory, Translational UroOncology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany;Department of Urology, Urological Research Laboratory, Translational UroOncology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany;Department of Urology, University Hospital Ulm, Ulm, Germany;Genomics & Transcriptomics Laboratory, Heinrich Heine University Düsseldorf, Düsseldorf, Germany;Institute of Pathology, University Medical Centre Göttingen, Göttingen, Germany;

关键词: Germ cell tumor;    Therapy;    Epi-drugs;    Histone modification;    Epigenetic modifier;    Epigenetics;    Histone deacetylase inhibitor;    Histone demethylase inhibitor;    Histone methyltransferase inhibitor;    PROTAC;   

DOI  :  10.1186/s13148-021-01223-1

来源: Springer

【 授权许可】

CC BY