Epigenetic modifications in colorectal cancer: Molecular insights and therapeutic challenges

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1842

Review

Vaiopoulos, Aristeidis G.¹  Athanasoula, Kalliopi Ch.¹  Papavassiliou, Athanasios G.¹ 

[1] Univ Athens, Dept Biol Chem, Sch Med, Athens 11527, Greece

关键词: Colorectal cancer;    Epigenetics;    Histone modification;    DNA methylation;    Therapy;    Prognosis;   

DOI  :  10.1016/j.bbadis.2014.02.006

来源: Elsevier

【 摘 要 】

Colorectal cancer, a leading cause of mortality worldwide, is a multistep disorder that results from the alteration of genetic and epigenetic mechanisms under contextual influence. Epigenetic aberrations, including DNA methylation, histone modifications, chromatin remodeling and non-coding RNAs, affect every aspect of tumor development from initiation to metastasis. Cancer stem cell promotion is also included in the wide spectrum of epigenetic dysregulations. Elucidation of this complex crosstalk network may offer new insights in the molecular interactions involved in the pathogenesis of colorectal carcinogenesis. In the era of translational medicine new horizons are opened for the pursuit of personalized therapeutic approaches and the development of novel and accurate diagnostic, prognostic and therapy-assessment markers. This review discusses the implications of epigenetic mechanisms in tumor biology and their applications from bench to bedside. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

Free