Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy

Molecular Cancer

Yau-Tuen Chan¹  Yibin Feng¹  Sha Li¹  Yuanjun Lu¹  Hor-Yue Tan¹  Ning Wang¹ 

[1] School of Chinese Medicine, The University of Hong Kong;

关键词: Epigenetic modification;    Cancer;    Epi-drugs;    Combination strategy;    Tumour microenvironment;   

DOI  :  10.1186/s12943-020-01197-3

来源: DOAJ

【 摘 要 】

Abstract Epigenetics is dynamic and heritable modifications to the genome that occur independently of DNA sequence. It requires interactions cohesively with various enzymes and other molecular components. Aberrant epigenetic alterations can lead to inappropriate onset of genetic expressions and promote tumorigenesis. As the epigenetic modifiers are susceptible to extrinsic factors and reversible, they are becoming promising targets in multiple cancer therapies. Recently, various epi-drugs have been developed and implicated in clinical use. The use of epi-drugs alone, or in combination with chemotherapy or immunotherapy, has shown compelling outcomes, including augmentation of anti-tumoral effects, overcoming drug resistance, and activation of host immune response.

【 授权许可】

Unknown