The role of Exosomal miRNAs in cancer

Journal of Translational Medicine

Rong Li¹  Cao Cai²  Huan Chen²  Chuanyun Li²  Weihua Li³  Dexi Chen³  Jing Chen³  Shumin Luo³  Tong Zhou⁴ 

[1] Chengde Medical University, Chengde, China;Fengtai District, YouAn Hospital, Capital Medical University, NO. 8, Xitoutiao, Youanmen wai, Beijing, China;Fengtai District, YouAn Hospital, Capital Medical University, NO. 8, Xitoutiao, Youanmen wai, Beijing, China;Beijing Institute of Hepatology, Beijing, China;Xiangya School of Medicine, Central South University, Changsha, China;

关键词: Exosome;    miRNAs;    Cancer;    Treatment resistance;   

DOI  :  10.1186/s12967-021-03215-4

来源: Springer

【 摘 要 】

Exosomal miRNAs have attracted much attention due to their critical role in regulating genes and the altered expression of miRNAs in virtually all cancers affecting humans (Sun et al. in Mol Cancer 17(1):14, 2018). Exosomal miRNAs modulate processes that interfere with cancer immunity and microenvironment, and are significantly involved in tumor growth, invasion, metastasis, angiogenesis and drug resistance. Fully investigating the detailed mechanism of miRNAs in the occurrence and development of various cancers could help not only in the treatment of cancers but also in the prevention of malignant diseases. The current review highlighted recently published advances regarding cancer-derived exosomes, e.g., sorting and delivery mechanisms for RNAs. Exosomal miRNAs that modulate cancer cell-to-cell communication, impacting tumor growth, angiogenesis, metastasis and multiple biological features, were discussed. Finally, the potential role of exosomal miRNAs as diagnostic and prognostic molecular markers was summarized, as well as their usefulness in detecting cancer resistance to therapeutic agents.

【 授权许可】

CC BY