Exosomes: an overview of biogenesis, composition and role in ovarian cancer

Journal of Ovarian Research

Sham S Kakar³  Mariusz Z Ratajczak³  Huang-Ge Zhang²  Allison Beach¹ 

[1] Department of Physiology and Biophysics, James Graham Brown Cancer Center, University of Louisville, 505 South Hancock Street, Louisville, KY 40202, USA;Department of Microbiology and Immunology, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA;Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA

关键词: Cancer diagnosis;    Microvesicle;    Cancer;    Ovarian cancer;    Exosome;   

Others  :  802070
DOI  :  10.1186/1757-2215-7-14

 received in 2013-11-28, accepted in 2014-01-22,  发布年份 2014

【 摘 要 】

Exosomes are tiny membrane-bound vesicles that are over produced by most proliferating cell types during normal and pathological states. Their levels are up-regulated during pregnancy and disease states such as cancer. Exosomes contain a wide variety of proteins, lipids, RNAs, non-transcribed RNAs, microRNAs and small RNAs that are representative to their cellular origin and shuttle from a donor cell to a recipient cell. From intercellular communication to tumor proliferation, exosomes carry out a diverse range of functions, both helpful and harmful. Useful as biomarkers, exosomes may be applicable in diagnostic assessments as well as cell-free anti-tumor vaccines. Exosomes of ovarian cancer contain different set of proteins and miRNAs compared to exosomes of normal, cancer-free individuals. These molecules may be used as multiple “barcode” for the development of a diagnostic tool for early detection of ovarian cancer.

【 授权许可】

   
2014 Beach et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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