Semiconductor quantum dot toxicity in a mouse in vivo model

1st International Symposium 'Physics, Engineering and Technologies for Bio-Medicine'

医药卫生;物理学;工业技术

Bozrova, Svetlana V.^1 ; Baryshnikova, Maria A.^1,2 ; Nabiev, Igor^1,3 ; Sukhanova, Alyona^1,3

Laboratory of Nano-Bioengineering, National Research Nuclear University, MEPhI (Moscow Engineering Physics Institute), Moscow

115522, Russia^1

Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

115478, Russia^2

Laboratoire de Recherche en Nanosciences, EA4682-LRN, Université de Reims Champagne-Ardenne, Reims

51100, France^3

关键词: Cancer diagnosis;    CdSe/ZnS;    Clinical medicine;    Core/shell;    Fluorescent semiconductors;    In-vivo;    In-vivo experiments;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/784/1/012013/pdf
DOI  :  10.1088/1742-6596/784/1/012013

来源: IOP

【 摘 要 】

Quantum dots (QDs) are increasingly widely used in clinical medicine. Their most promising potential applications are cancer diagnosis, including in vivo tumour imaging and targeted drug delivery. In this connection, the main questions are whether or not QDs are toxic for humans and, if they are, what concentration is relatively harmless. We have carried out in vivo experiments with CdSe/ZnS fluorescent semiconductor core/shell QDs, which are currently the most widely used in research.