Arthritis Research & Therapy | |
A new and spontaneous animal model for ankylosing spondylitis is found in cynomolgus monkeys | |
Huiyong Shen1  Gang Hou2  Sin-Hang Fung3  Kai-Kei Miu3  Zhangting Wang3  Meili Chen4  Ren Huang4  Yongfeng Li5  Li Lu6  Jun Chen6  Yanzhen Cai6  Xiaoling Luo6  Chunmei Cai6  Qingnan Li7  Huanhuan Jia7  | |
[1] Department of Orthopedics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China;Department of Orthopedics, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China;Developmental and Regenerative Biology Theme, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China;Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China;Guangzhou Blooming-Spring Biological Research Institute, Guangzhou, China;School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, China;School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, China;Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China; | |
关键词: Ankylosing spondylitis; Cynomolgus monkeys; Animal model; Spontaneous; Hematological testing; Radiographic examination; Family aggregation analysis; Pathological analysis; | |
DOI : 10.1186/s13075-021-02679-5 | |
来源: Springer | |
【 摘 要 】
BackgroundAnkylosing spondylitis is a progressive, disabling joint disease that affects millions worldwide. Given its unclear etiology, studies of ankylosing spondylitis relied heavily on drug-induced or transgenic rodent models which retain only partial clinical features. There is obviously a lack of a useful disease model to conduct comprehensive mechanistic studies.MethodsWe followed a group of cynomolgus monkeys having joint lesions reported of spinal stiffness for 2 years by conducting hematological testing, radiographic examination, family aggregation analysis, pathological analysis, and genetic testing.ResultsThe results confirmed that these diseased animals suffered from spontaneous ankylosing spondylitis with clinical features recapitulating human ankylosing spondylitis disease progression, manifested by pathological changes and biochemical indicators similar to that of ankylosing spondylitis patients.ConclusionThe study offers a promising non-human primate model for spontaneous ankylosing spondylitis which may serve as an excellent substitute for its pre-clinical research.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202203110853686ZK.pdf | 4562KB | download |