A new and spontaneous animal model for ankylosing spondylitis is found in cynomolgus monkeys

Arthritis Research & Therapy

Huiyong Shen¹  Gang Hou²  Sin-Hang Fung³  Kai-Kei Miu³  Zhangting Wang³  Meili Chen⁴  Ren Huang⁴  Yongfeng Li⁵  Li Lu⁶  Jun Chen⁶  Yanzhen Cai⁶  Xiaoling Luo⁶  Chunmei Cai⁶  Qingnan Li⁷  Huanhuan Jia⁷ 

[1]Department of Orthopedics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China

[2]Department of Orthopedics, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

[3]Developmental and Regenerative Biology Theme, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

[4]Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China

[5]Guangzhou Blooming-Spring Biological Research Institute, Guangzhou, China

[6]School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, China

[7]School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, China

[8]Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China

关键词: Ankylosing spondylitis;    Cynomolgus monkeys;    Animal model;    Spontaneous;    Hematological testing;    Radiographic examination;    Family aggregation analysis;    Pathological analysis;   

DOI  :  10.1186/s13075-021-02679-5

来源: Springer

【 摘 要 】

BackgroundAnkylosing spondylitis is a progressive, disabling joint disease that affects millions worldwide. Given its unclear etiology, studies of ankylosing spondylitis relied heavily on drug-induced or transgenic rodent models which retain only partial clinical features. There is obviously a lack of a useful disease model to conduct comprehensive mechanistic studies.MethodsWe followed a group of cynomolgus monkeys having joint lesions reported of spinal stiffness for 2 years by conducting hematological testing, radiographic examination, family aggregation analysis, pathological analysis, and genetic testing.ResultsThe results confirmed that these diseased animals suffered from spontaneous ankylosing spondylitis with clinical features recapitulating human ankylosing spondylitis disease progression, manifested by pathological changes and biochemical indicators similar to that of ankylosing spondylitis patients.ConclusionThe study offers a promising non-human primate model for spontaneous ankylosing spondylitis which may serve as an excellent substitute for its pre-clinical research.

【 授权许可】

CC BY