High serum allograft inflammatory factor 1 is associated with poor response to TNFα inhibitors in ankylosing spondylitis patients

Ankylosing spondylitis;anti-TNF;allograft inflammatory factor 1;AIF1;BASDAI;serum marker;610

의과대학 의학과 ;

University:서울대학교 대학원

关键词: Ankylosing spondylitis;    anti-TNF;    allograft inflammatory factor 1;    AIF1;    BASDAI;    serum marker;    610;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/142331/1/000000151165.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

91.0] pg/ml in nonresponders(p=0.033). AIF1 level of 63.5 pg/ml or more was associatedwith higher risk for BASDAI > 5.0 at week 14 after anti-TNFα treatment (adjusted OR 6.953, p=0.002).Conclusion: Baseline serum AIF1 level was higher in TNFα blocker non-responders. After adjusting age and initial BASDAI, high concentration of baseline AIF1 was associated with high disease activity after TNFα blocker treatment. These results suggest that AIF1 may be a novel serum marker for predicting non-responders to anti-TNFα therapy in AS.