Delirium and other neuropsychiatric manifestations of COVID-19 infection in people with preexisting psychiatric disorders: a systematic review

Journal of Medical Case Reports

Lawrence Mbuagbaw¹  Lehana Thabane²  Julia Woo³  Emma A. van Reekum³  Tea Rosic⁴  Alexander Dufort⁴  Zainab Samaan⁵  Myanca Rodrigues⁶  Stephanie Sanger⁷  Nitika Sanger⁸  Reid Rebinsky⁹  Nayeon Kim⁹  Anjali Sergeant⁹  Eve Deck⁹  Alessia D’Elia^1,10  Alannah Hillmer^1,10  Balpreet Panesar^1,10 

[1] Department of Health Research, Evidence and Impact, McMaster University, Hamilton, Canada;Department of Health Research, Evidence and Impact, McMaster University, Hamilton, Canada;St. Joseph’s Healthcare Hamilton, 100 West 5th Street, L8N 3K7, Hamilton, ON, Canada;Department of Psychiatry and Behavioural Neurosciences, Clinician Investigator Program, McMaster University, Hamilton, Canada;Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada;Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada;Department of Health Research, Evidence and Impact, McMaster University, Hamilton, Canada;Health Research Methodology Graduate Program, McMaster University, Hamilton, Canada;Health Sciences Library, McMaster University, Hamilton, Canada;Medical Science Graduate Program, McMaster University, Hamilton, Canada;Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada;Neuroscience Graduate Program, McMaster University, Hamilton, Canada;

关键词: Delirium;    Mental disorders;    COVID-19;    Internal medicine;    Pandemic;    Psychiatric disorder;    Systematic review;    Case reports;   

DOI  :  10.1186/s13256-021-03140-6

来源: Springer

【 摘 要 】

BackgroundPsychiatric disorders increase risk of neuropsychiatric disease and poor outcomes, yet little is known about the neuropsychiatric manifestations of COVID-19 in the psychiatric population. The primary objective is to synthesize neuropsychiatric outcomes of COVID-19 in people with preexisting psychiatric disorders.MethodsData were collected during an ongoing review of the impact of pandemics on people with existing psychiatric disorders. All study designs and gray literature were included. Medline, PsychInfo, CINAHL, EMBASE, and MedRx were searched from inception to September 1 2020. Risk of bias was assessed using a published tool that can accommodate all study types. Two independent authors screened the studies and extracted data. Data were narratively synthesized, as there were insufficient data to meta-analyze. Evidence was appraised according to GRADE.ResultsFour case reports were included, comprising 13 participants from three countries. Many large-sample, relevant papers were omitted for not reporting psychiatric history, despite reporting other comorbidities. Included participants (n = 13) were hospitalized with COVID-19 and appeared to meet criteria for delirium. Myoclonus, rigidity, and alogia were also reported. The most commonly reported preexisting psychiatric diagnoses were mood disorders, schizophrenia, and alcohol use disorder.ConclusionsPeople with preexisting psychiatric disorders may experience delirium, rigidity, myoclonus, and alogia during COVID-19 infection; although higher quality and longitudinal data are needed to better understand these phenomena. Relevant COVID-19 literature does not always report psychiatric history, despite heightened neuropsychiatric vulnerability within this population.Trial Registration: PROSPERO (CRD42020179611).

【 授权许可】

CC BY