The worsening factors of dengue hemorrhagic fever (DHF) based on cohort study with nested case-control in a tertiary hospital

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Lardo, S.^1 ; Soesatyo, M.H.N.E.^2 ; Juffrie^3 ; Umniyati, S.R.^4

Division of Tropical Medicine and Infectious Diseases, Department of Internal Medicine, Indonesia Army Central Hospital Gatot Soebroto, Jakarta, Indonesia^1

Department of Histology and Cell Biology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia^2

Departement of Pediatrics, Faculty of Medicine, Universitas Gadjah Mada, Sardjito Hospital, Yogyakarta, Indonesia^3

Departement of Parasitology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia^4

关键词: Case-control study;    Central hospitals;    Clinical pathways;    Cohort studies;    Dengue hemorrhagic fever;    Internal medicine;    Pathophysiological;    Systolic blood pressure;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012011/pdf
DOI  :  10.1088/1755-1315/125/1/012011

来源: IOP

【 摘 要 】

The clinical pathway of DHF has a broad pathophysiological and pathogenesis spectrum. Clinical and laboratory characteristics are some of the parameters to determine the factors that contribute to the worsening of the disease. The objective of this study is to determine the clinical and laboratory characteristics which contribute to the worsening of DHF. The study had been conducted from January 2012-December 2014 at the general ward of the Internal Medicine Department, Indonesia Army Central Hospital Gatot Soebroto. There were 101 male patients (64.7%) and 55 female patients (35.3 %) ages ranging from 14 - 62 years old. The diagnosis was divided into: 124 patients DHF grade I, 6 DHF grade II, 20 DHF grade III and 6 with dengue shock syndrome (DSS) patients. Clinically and statistically, there were 4 variables apparently found with the severity of DHF, as follows: decreased appetite with p = 0.007 (OR 4.87), hepatomegaly with p = 0.009 (OR 27.00), systolic blood pressure with p = 0.037 (OR 0.95), and initial thrombocyte with p = 0.000 (OR 0.97). This cohort and nested case-control study found that worsening of DHF is related with decreased appetite, hepatomegaly, systolic blood pressure and initial thrombocyte count.