Editing out HIV: application of gene editing technology to achieve functional cure

Retrovirology

Jun Chen¹  Hongzhou Lu¹  Xinyu Zhang²  Jingna Xun³  Shuyan Guo⁴ 

[1] Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Road, 201508, Shanghai, China;Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Road, 201508, Shanghai, China;Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Road, 201508, Shanghai, China;State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China;Shanghai Foreign Language School, Shanghai International Studies University, Shanghai, China;

关键词: HIV/AIDS;    Highly active antiretroviral therapy;    Gene editing;    Functional cure;   

DOI  :  10.1186/s12977-021-00581-1

来源: Springer

【 摘 要 】

Highly active antiretroviral therapy (HAART) successfully suppresses human immunodeficiency virus (HIV) replication and improves the quality of life of patients living with HIV. However, current HAART does not eradicate HIV infection because an HIV reservoir is established in latently infected cells and is not recognized by the immune system. The successful curative treatment of the Berlin and London patients following bone marrow transplantation inspired researchers to identify an approach for the functional cure of HIV. As a promising technology, gene editing-based strategies have attracted considerable attention and sparked much debate. Herein, we discuss the development of different gene editing strategies in the functional cure of HIV and highlight the potential for clinical applications prospects.Graphical Abstract

【 授权许可】

CC BY