Effect of isoniazid preventive therapy on tuberculosis incidence in people living with HIV-AIDS at Hasan Sadikin hospital

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Satiavan, I.^1 ; Hartantri, Y.^1 ; Werry, B.^1 ; Nababan, Y.^1 ; Wisaksana, R.^1 ; Alisjahban, B.^1

Program of Internal Medicine Specialist, Tropical Infectious Disease Division, Internal Medicine Department, Faculty of Medicine, Padjadjaran University, Hasan Sadikin Hospital Bandung West Java, Family Health International, Jakarta, Indonesia^1

关键词: Cohort studies;    HIV/AIDS;    Indonesia;    Infected patients;    Medical record;    Protective effects;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012006/pdf
DOI  :  10.1088/1755-1315/125/1/012006

来源: IOP

【 摘 要 】

Indonesia is the second largest number of tuberculosis (TB) in the world. Isoniazid Preventive Therapy (IPT) as one of the three I's TB-HIV collaboration to manage TB in people living with HIV / AIDS (PLHIV) has not been fully performed. It is related to doubt to get rid of TB in PLHIV. This study aims to see the effect of IPT on the incidence of TB in PLHIV. This issue is a retrospective cohort study based on medical record data in HIV clinic. Inclusion criteria are PLHIV ≥ 15 years of age who were registered to visit the CST service and obtain IPT with good adherence if they were receiving ART. Of 462 patients, HIV- infected patients receiving IPT were 154 (33.3%). IPT administration has a protective effect on PLHIV where the rate of TB incidence in PLHIV who received IPT were 0.21 times lower than those who did not receive IPT (IRR = 0.21, 95% CI 0.023-0.881, p 0.008). In this population, IPT administration reduces 79% risk of PLHIV to suffer TB.IPT administration reduces the incidence of TB.