Administration of zinc to preterm infants with hypozincemia does not reduce serum copper concentrations in most cases: a single-center retrospective observational study

Journal of Pharmaceutical Health Care and Sciences

Hiroshi Mizumoto¹  Masahide Onoue²  Kazuhiro Kobayashi²  Kazuya Uenoyama²  Toshikazu Ito³  Toshiya Katsura⁴  Mikio Kakumoto⁵ 

[1]Department of Pediatrics, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, 530-8480, Osaka, Japan

[2]Department of Pharmacy, Kitano Hospital, Tazuke Kofukai Medical Research Institute. 2-4-20, Ogimachi, Kita-ku, 530-8480, Osaka, Japan

[3]Department of Pharmacy, Kitano Hospital, Tazuke Kofukai Medical Research Institute. 2-4-20, Ogimachi, Kita-ku, 530-8480, Osaka, Japan

[4]Laboratory of Clinical Pharmaceutics and Therapeutics, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1, Noji-higashi, 525-8577, Kusatsu, Shiga, Japan

[5]Laboratory of Clinical Pharmaceutics and Therapeutics, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1, Noji-higashi, 525-8577, Kusatsu, Shiga, Japan

[6]Laboratory of Clinical Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1, Noji-higashi, 525-8577, Kusatsu, Shiga, Japan

关键词: Preterm infants;    Zinc;    Copper;    Serum concentration;    Hypozincemia;   

DOI  :  10.1186/s40780-021-00229-4

来源: Springer

【 摘 要 】

BackgroundZinc is an essential trace element involved in various physiological functions. In Japan, zinc acetate dihydrate is administered to neonates and infants with hypozincemia. Since serum copper concentrations are reduced by the administration of zinc, we retrospectively investigated changes in serum zinc and copper concentrations in preterm infants with hypozincemia receiving zinc acetate dihydrate.MethodsSixty-three preterm infants were included in the present study. Serum zinc and copper concentrations, doses, and other clinical characteristics were retrieved from electronic medical records.ResultsThe medians and interquartile ranges of the dosage and duration of zinc acetate dihydrate were 2.1 (1.8–2.5) mg/kg/day and 12.0 (10.0–13.0) days, respectively. Its administration increased serum zinc concentrations in 39 patients (61.9%) and to more than 70 μg/dL in 16 patients (25.4%). The group with a serum zinc concentration of 70 μg/dL or higher after administration had a significantly higher zinc dose of 2.5 mg/kg/day than the group with a serum zinc concentration of less than 70 μg/dL. Serum copper concentrations did not decrease in 44 patients (69.8%). In the group with a decreased serum copper concentration, postmenstrual age and body weight were significantly lower, while serum zinc concentrations were significantly higher at the start of administration.ConclusionThe present results showed that when zinc acetate dihydrate was administered to preterm infants with hypozincemia, it was possible to increase serum zinc concentrations without decreasing serum copper concentrations in many cases. However, caution may be required when administering zinc to preterm infants with a lower postmenstrual age or milder hypozincemia because serum copper concentrations may decrease.

【 授权许可】

CC BY