Regulated cell death: discovery, features and implications for neurodegenerative diseases

Cell Communication and Signaling

Junxia Xie¹  Juntao Cui²  Bingjing Wang²  Yinghui Li²  Danyang Zhang²  Jun Wang²  Suhan Zhao³ 

[1] Institute of Brain Science and Disease, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, 266071, Qingdao, China;School of Basic Medicine, Qingdao University, 266071, Qingdao, China;Institute of Brain Science and Disease, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, 266071, Qingdao, China;School of Basic Medicine, Qingdao University, 266071, Qingdao, China;School of Clinical Medicine, Qingdao University, 266071, Qingdao, China;

关键词: Apoptosis;    Pyroptosis;    Autophagy-dependent cell death;    Necroptosis;    Ferroptosis;   

DOI  :  10.1186/s12964-021-00799-8

来源: Springer

【 摘 要 】

Regulated cell death (RCD) is a ubiquitous process in living organisms that is essential for tissue homeostasis or to restore biological balance under stress. Over the decades, various forms of RCD have been reported and are increasingly being found to involve in human pathologies and clinical outcomes. We focus on five high-profile forms of RCD, including apoptosis, pyroptosis, autophagy-dependent cell death, necroptosis and ferroptosis. Cumulative evidence supports that not only they have different features and various pathways, but also there are extensive cross-talks between modes of cell death. As the understanding of RCD pathway in evolution, development, physiology and disease continues to improve. Here we review an updated classification of RCD on the discovery and features of processes. The prominent focus will be placed on key mechanisms of RCD and its critical role in neurodegenerative disease.By_JunfWdadRA1LZr1KgqbVideo abstractGraphical Abstract

【 授权许可】

CC BY