Radiotherapy modulates tumor cell fate decisions: a review

Radiation Oncology

Review

Houdong Zuo¹  Qian Luo¹  Lisui Zhou¹  Haoran Chen¹  Yi Wang¹  Qiju Li¹  Zhongyu Han² 

[1] Chengdu Xinhua Hospital, Chengdu, China;Chengdu Xinhua Hospital, Chengdu, China;School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China;

关键词: Radiotherapy;    Apoptosis;    Necrosis;    Necroptosis;    Senescence;    Mitotic catastrophe;    Autophagy;    Pyroptosis;    Ferroptosis;    Cuproptosis;   

DOI  :  10.1186/s13014-022-02171-7

 received in 2022-09-01, accepted in 2022-11-29,  发布年份 2022

来源: Springer

【 摘 要 】

Cancer has always been a worldwide problem, and the application of radiotherapy has greatly improved the survival rate of cancer patients. Radiotherapy can modulate multiple cell fate decisions to kill tumor cells and achieve its therapeutic effect. With the development of radiotherapy technology, how to increase the killing effect of tumor cells and reduce the side effects on normal cells has become a new problem. In this review, we summarize the mechanisms by which radiotherapy induces tumor cell apoptosis, necrosis, necroptosis, pyroptosis, ferroptosis, autophagy, senescence, mitotic catastrophe, and cuproptosis. An in-depth understanding of these radiotherapy-related cell fate decisions can greatly improve the efficiency of radiotherapy for cancer.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 2