Research progress on multiple cell death pathways of podocytes in diabetic kidney disease

Molecular Medicine

Review

Yanhui Chu¹  Can Yang²  Haiying Shu²  Luxin Li²  Peijian Chen²  Jieting Liu²  Jialing Li²  Zhen Zhang³ 

[1] College of Life Sciences, Mudanjiang Medical University, 157000, Mudanjiang, China;Heilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, 157000, Mudanjiang, China;College of Life Sciences, Mudanjiang Medical University, 157000, Mudanjiang, China;Heilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, 157000, Mudanjiang, China;School of First Clinical Medical College, Mudanjiang Medical University, 157000, Mudanjiang, China;

关键词: Diabetic kidney disease;    Podocyte;    Apoptosis;    Autophagy;    Endoplasmic reticulum stress;    Pyroptosis;    Necroptosis;    Ferroptosis;    Mitotic catastrophe;   

DOI  :  10.1186/s10020-023-00732-4

 received in 2023-07-14, accepted in 2023-09-18,  发布年份 2023

来源: Springer

【 摘 要 】

Diabetic kidney disease (DKD) is the main cause of end-stage renal disease, and its clinical manifestations are progressive proteinuria, decreased glomerular filtration rate, and renal failure. The injury and death of glomerular podocytes are the keys to DKD. Currently, a variety of cell death modes have been identified in podocytes, including apoptosis, autophagy, endoplasmic reticulum (ER) stress, pyroptosis, necroptosis, ferroptosis, mitotic catastrophe, etc. The signaling pathways leading to these cell death processes are interconnected and can be activated simultaneously or in parallel. They are essential for cell survival and death that determine the fate of cells. With the deepening of the research on the mechanism of cell death, more and more researchers have devoted their attention to the underlying pathologic research and the drug therapy research of DKD. In this paper, we discussed the podocyte physiologic role and DKD processes. We also provide an overview of the types and specific mechanisms involved in each type of cell death in DKD, as well as related targeted therapy methods and drugs are reviewed. In the last part we discuss the complexity and potential crosstalk between various modes of cell death, which will help improve the understanding of podocyte death and lay a foundation for new and ideal targeted therapy strategies for DKD treatment in the future.

【 授权许可】

CC BY   
© The Feinstein Institute for Medical Research 2023

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