Semi-automated histogram analysis of normal bone marrow using 18F-FDG PET/CT: correlation with clinical indicators

BMC Medical Imaging

Keita Kirito¹  Hiroshi Onishi²  Satoshi Funayama²  Yoko Satoh³ 

[1] Department of Hematology and Oncology, University of Yamanashi, Shimokato 1110, 409-3898, Chuo City, Yamanashi Prefecture, Japan;Department of Radiology, University of Yamanashi, Shimokato 1110, 409-3898, Chuo City, Yamanashi Prefecture, Japan;Yamanashi PET Imaging Clinic, Shimokato 3046-2, 409-3821, Chuo City, Yamanashi Prefecture, Japan;Department of Radiology, University of Yamanashi, Shimokato 1110, 409-3898, Chuo City, Yamanashi Prefecture, Japan;

关键词: F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT);    Bone marrow;    Semi-automatic extraction;    Normal uptake pattern;    Histogram analysis;   

DOI  :  10.1186/s12880-022-00757-x

来源: Springer

【 摘 要 】

Background18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is increasingly applied to the diagnosis of bone marrow failure such as myeloproliferative neoplasm, aplastic anemia, and myelodysplastic syndrome, as well as malignant lymphoma and multiple myeloma. However, few studies have shown a normal FDG uptake pattern. This study aimed to establish a standard of bone marrow FDG uptake by a reproducible quantitative method with fewer steps using deep learning-based organ segmentation.MethodsBone marrow PET images were obtained using segmented whole-spine and pelvic bone marrow cavity CT as mask images using a commercially available imaging workstation that implemented an automatic organ segmentation algorithm based on deep learning. The correlation between clinical indicators and quantitative PET parameters, including histogram features, was evaluated.ResultsA total of 98 healthy adults were analyzed. The volume of bone marrow PET extracted in men was significantly higher than that in women (p < 0.0001). Univariate and multivariate regression analyses showed that mean of standardized uptake value corrected by lean body mass (SULmean) and entropy in both men and women were inversely correlated with age (all p < 0.0001), and SULmax in women were also inversely correlated with age (p = 0.011).ConclusionA normal FDG uptake pattern was demonstrated by simplified FDG PET/CT bone marrow quantification.

【 授权许可】

CC BY