Antioxidant and genoprotective properties of the antidiabetic drug metformin under X-ray irradiation

2nd International (15th Regional) Scientific Conference "Technogenic Systems and Environmental Risk"

工业技术（总论）;生态环境科学

Karmanova, E.E.^1 ; Abdullaev, S.A.^1 ; Ivanov, V.E.^1 ; Minkabirova, G.M.^1 ; Bruskov, V.I.^1

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region

142290, Russia^1

关键词: 8-oxoguanine;    Anti-Diabetic Drugs;    Bone marrow;    Hydroxyl radicals;    In-vitro;    Metformins;    Oxidative damage;    X ray irradiation;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/487/1/012023/pdf
DOI  :  10.1088/1757-899X/487/1/012023

来源: IOP

【 摘 要 】

The antioxidant and genoprotective properties of the antidiabetic drug metformin have been investigated. The research was performed both in vitro and in vivo under X-ray irradiation. It was shown that metformin reduced the formation of hydroxyl radicals and hydrogen peroxide in aqueous solutions irradiated with X-rays. The particular features of its influence on the formation of H2O2 were revealed. It has been established that metformin reduced the formation of 8-oxoguanine, a key biomarker of oxidative damage to DNA, in vitro. The effect of metformin on the frequency of micronucleus formation in polychromatic erythrocytes of bone marrow of irradiated mice was investigated. Its genoprotective and radiomimitatory properties at different concentrations and times of application are shown.