Biocompatible interpolymer complex matrix tablets - an oral sustained release class-III antidiabetic drug

14th International Conference on Science, Engineering and Technology

自然科学;工业技术

Ershadul Haque, S.K.^1,2 ; Sheela, A.^1

Department of Chemistry, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu

632 014, India^1

Narayana Pharmacy College, Chintha Reddy Palem, Nellore, Pin

524002, India^2

关键词: Anti-Diabetic Drugs;    Drug delivery system;    Fourier transform infra red (FTIR) spectroscopy;    Hydroxypropyl methylcellulose;    Interpolymer complexes;    Metformin hydrochlorides;    Polymeric matrices;    Powder X ray diffraction;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/263/2/022030/pdf
DOI  :  10.1088/1757-899X/263/2/022030

来源: IOP

【 摘 要 】

Development of sustained release formulations of Metformin hydrochloride (Met) having low bioavailability and short half-life is one of the frontier areas of research towards achieving novel drug delivery systems. Towards the same, we have prepared interpolymer complexes (IPCs) of chitosan (CH) and two different viscosity grades of hydroxypropyl methylcellulose-HPMC (K4M and K100M) in various ratios, say, 4:6, 2:8, 1:9, respectively. The IPCs are characterized by Fourier transform infrared spectroscopy (FT-IR) and Thermo gravimetric analysis (TGA) techniques. Drug compatibility study is carried out by FT-IR and powder X-ray diffraction (XRD) techniques. The physical properties and drug content of formulated tablets are evaluated and found to be optimum. In addition, in vitro drug release kinetics is carried out at two different pH, say, 1.2 and 6.8. The release pattern from different polymeric matrices is shown in figure below: a) Chitosan, HPMC K4M and HPMC K100M b) IPCs of CH/HPMC K4M in [2:3, 1:4 and 1:9 ratios] c) IPCs of CH/HPMC K100M in [2:3, 1:4 and 1:9 ratios]. From the study, it has been observed that the drug release is sustained for a period of 12h in 1:9 ratio of CH: K100M IPC due to the formation of complex network matrix.