Synthesis and characterization of carboxyl modifiedmesoporous silica nanoparticles with disulfide bond as a cross linker

6th Annual International Conference on Material Science and Engineering

Wang, Youyun^1,2,3,4 ; Wang, Wanxia^1,2,3,4 ; Wang, Yu^1,2,3,4 ; Liu, Mingxing^1,2,3,4

Key Laboratory of Fermentation Engineering, Ministry of Education, China^1

Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, China^2

National 111 Center for Cellular Regulation and Molecular Pharmaceutics, China^3

Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan

430068, China^4

关键词: Disulfide bonds;    Disulfide exchange;    Drug delivery system;    Fourier transform infra red (FTIR) spectroscopy;    Mesoporous silica nanoparticles;    Novel strategies;    Spherical morphologies;    Synthesis and characterizations;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/397/1/012004/pdf
DOI  :  10.1088/1757-899X/397/1/012004

来源: IOP

【 摘 要 】

The purpose of this article is to prepare and characterize the disulfide bond and carboxyl-bifunctionalized colloidal mesoporous silica nanoparticles (CMS-SS-COOH). The CMS-SS-COOH was successfully synthesized by disulfide exchange and admiration methods. Moreover, the particle size and structural properties of CMS-SS-COOH were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and fourier transform infrared spectroscopy (FT-IR).The results showed that the nanomaterials had a relatively uniform spherical morphology witha diameter of ca. 80 nm. This papermight provide a novel strategy to construct a stimulu-responsive drug delivery system in the future.