The polyoxyethylene/polyoxypropylene block co‐polymer Poloxamer‐407 selectively redirects intravenously injected microspheres to sinusoidal endothelial cells of rabbit bone marrow

FEBS Letters

Moghimi, S.Moein¹  Illum, Lisbeth¹  Davis, Stanley S.¹  Porter, Christopher J.H.¹ 

[1]Department of Pharmaceutical Sciences, University of Nottingham, Nottingham NG7 2RD, UK

关键词: Microsphere;    Bone marrow;    Endothelial cell;    Poloxamer-4O7;    Rabbit;   

DOI  :  10.1016/0014-5793(92)80655-Z

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Small colloidal particulates (150 nm and below, in diameter) can be redirected specifically to the rabbit bone marrow following intravenous administration by coating their surface with the block co-polymer poloxamer-407, a non-ionic surfactant. The coated colloids are sequestered by the sinusoidal endothelial cells of the bone marrow and are accumulated in dense bodies within these cells. The uptake of poloxamer-4O7-coated colloids by marrow eondothelial cells suggests that the steric repulsive barrier, imposed by the polyoxyethylene segment of the polymer, to particle-cell interaction can apparently be overcome by a specific interaction mechanism(s) with the cell surface. Such a dramatic uptake cannot be achieved with other block co-polymers of similar structure to poloxamer-407. The application of the current model for the site-specific targeting or drug carriers to bone marrow and the prevention of the adherence of metastases of tumours which selectively colonize the bone marrow endothelium is discussed.

【 授权许可】

Unknown